Regulation of smooth muscle myosin
نویسندگان
چکیده
منابع مشابه
Regulation of arterial tone by smooth muscle myosin type II.
The initiation of contractile force in arterial smooth muscle (SM) is believed to be regulated by the intracellular Ca2+ concentration and SM myosin type II phosphorylation. We tested the hypothesis that SM myosin type II operates as a molecular motor protein in electromechanical, but not in protein kinase C (PKC)-induced, contraction of small resistance-sized cerebral arteries. We utilized a S...
متن کاملRegulation of the interaction between smooth muscle myosin and actin.
Phosphorylation of the regulatory light chain of smooth muscle myosin efficiently regulates the actin-activated ATPase activity of myosin filaments in solution and actin movement in an in vitro motility assay, independently of thin-filament regulatory proteins. Filaments containing both phosphorylated and dephosphorylated heads move actin at intermediate rates, depending on the relative proport...
متن کاملInvited review: regulation of myosin phosphorylation in smooth muscle.
Phosphorylation of the regulatory light chains of myosin II (rMLC) by the Ca(2+)/calmodulin-dependent myosin light-chain kinase (MLCK) and dephosphorylation by a type 1 phosphatase (MLCP), which is targeted to myosin by a regulatory subunit (MYPT1), are the predominant mechanisms of regulation of smooth muscle tone. The activities of both enzymes are modulated by several protein kinases. MLCK i...
متن کاملSignal Transduction in Smooth Muscle Invited Review: Regulation of myosin phosphorylation in smooth muscle
Pfitzer, Gabriele. Invited Review: Regulation of myosin phosphorylation in smooth muscle. J Appl Physiol 91: 497–503, 2001.— Phosphorylation of the regulatory light chains of myosin II (rMLC) by the Ca21/calmodulin-dependent myosin light-chain kinase (MLCK) and dephosphorylation by a type 1 phosphatase (MLCP), which is targeted to myosin by a regulatory subunit (MYPT1), are the predominant mech...
متن کاملMyosin Phosphorylation and Crossbridge Regulation in Arterial Smooth Muscle
Regulation of rascuiar resistance is generally explained in terms of neural, hormonal, metabolic, and myogenic factors altering intracellular calcium [Ca] in vascular smooth muscle. Ca acts as a second messenger regulating the number of active crossbridges and force generation by binding to a myofilament regulatory protein. A search for the Ca-blndlng regulatory protein in arterial smooth muscl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Motility and the Cytoskeleton
سال: 1991
ISSN: 0886-1544,1097-0169
DOI: 10.1002/cm.970180202